Micro/Nano Encapsulation

Chemical Encapsulation Techniques

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	Using the SwRI pilot plant equipment and 200-liter reactors, SwRI chemists produce microspheres and synthesize kilogram batches of pharmaceuticals for phase one clinical trials.

Chemical encapsulation techniques typically yield particle dispersions that can be used as is or post-processed by other methods, such as spinning disk, spray drying or fluid bed to produce free-flowing powders.

 

Chemical Encapsulation Techniques

Southwest Research Institute (SwRI) has developed and practices several chemical encapsulation techniques, including:

• Solvent evaporation

• In situ polymerization

• Interfacial polymerization

• Emulsion polymerization

• Simple and complex coacervation

• Layer-by-layer deposition

• Liposomes

Chemical Encapsulation Applications

• Oil-in-water emulsions

• Water-in-oil emulsions

• Core-shell capsules or matrix particles

• Stable, high-solid dispersions

  	Layer-by-layer deposition adds new properties and stability to existing shell systems.

Chemical Encapsulation Characteristics

• Particle sizes from about 0.1 micron to 500 microns

• High payloads

• Uniform particle size distribution

• Scalability and high production capacity

• Batch production